C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/00 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2445985
A cell-targeted polymeric drug delivery system was designed based on the specific interaction between hyaluronic acid (HA) and its cell surface receptors overexpressed on cancer cell surface. The invention relates to compounds composed of a carrier molecule,5 wherein the carrier molecule contains at least one residue of an anti-cancer agent and at least one residue of a hyaluronic acid. The invention also relates to methods of making and using the compounds thereof.
L'invention concerne un système d'administration de médicament polymérique ciblé sur une cellule, lequel système se base sur l'interaction spécifique entre l'acide hyaluronique (HA) et ses récepteurs de surface cellulaire surexprimés à la surface d'une cellule cancéreuse. Cette invention concerne également des composés constitués d'une molécule porteuse, cette molécule porteuse contenant au moins un résidu d'un agent anticancéreux et au moins un résidu d'un acide hyaluronique. Cette invention concerne enfin des procédés de fabrication et d'utilisation de ces composés.
Kopecek Jindrich
Lu Zheng-Rong
Luo Yi
Prestwich Glenn D.
Gowling Lafleur Henderson Llp
University Of Utah Research Foundation
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