Hyaluronic acid derivatives obtained via "click chemistry"...

C - Chemistry – Metallurgy – 08 – B

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C08B 37/08 (2006.01) A61K 47/36 (2006.01) A61L 27/52 (2006.01)

Patent

CA 2662924

Crosslinked derivatives of polycarboxylated polysaccharides are described, wherein at least one of the polysaccharide chains consists of hyaluronic acid or a derivative thereof, crosslinked by means of reactions of the "click chemistry" type and their use in the field of viscosupplementation, plastic surgery, oncologic and reconstructive surgery and also as matrices for controlled release systems of biologically and/or pharmacologically active molecules and/or macromolecules.

L'invention concerne des dérivés réticulés de polysaccharides polycarboxylés, au moins une des chaînes des polysaccharides étant constituée d'acide hyaluronique ou d'un dérivé de ce dernier, réticulé par des réactions du type "click chemistry" (réaction de chimie clic). Elle concerne également leur utilisation dans les domaines de la viscosupplémentation, de la chirurgie plastique, de la chirurgie oncologique ou reconstructive, mais aussi comme matrices pour des systèmes à libération lente de molécules et/ou macromolécules biologiquement et/ou pharmacologiquement actives.

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