Hyaluronic acid fragments and their therapeutic use

Details Hyaluronic acid fragments and their therapeutic use Hyaluronic acid fragments and their therapeutic use

A - Human Necessities

61

L

A61L 27/00 (2006.01) A61K 31/73 (1995.01)

Patent

CA 2165826

Herein described are therapeutic compositions that contain, as active ingredient, hyaluronic acid fragments that are characterized structurally by a chain length of from 5 to 16 monosaccharides, and by a GlcNAc residue at the non-reducing end. A particularly preferred fragment is the nonameric GlcNAc-[GlcUA-GlcNAc]4. The fragments are useful particularly to effect localized bone repair, such as for the treatment of bone fracture.

L'invention se rapporte à des compositions thérapeutiques dont le principe actif est constitué de fragments d'acide hyaluronique caractérisés structurellement par une longueur de chaîne comprise entre 5 et 16 monosaccharides, et par un résidu de GlcNAc se situant à leur extrémité non réductrice. On préfère notamment le fragment nonamère GlcNAc-[GlcUA-GlcNAc]4. Ces fragments sont particulièrement utiles pour effectuer une réparation osseuse localisée telle que le traitement de la fracture osseuse.

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