C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/08 (2006.01) A61K 31/519 (2006.01) A61K 47/48 (2006.01) A61P 19/02 (2006.01) C07D 475/10 (2006.01) C07K 5/00 (2006.01)
Patent
CA 2559188
A hyaluronic acid/methotrexate compound useful as a therapeutic agent for joint diseases. The hyaluronic acid/methotrexate compound useful as a therapeutic agent for joint diseases comprises hyaluronic acid and methotrexate bonded to a carboxy group of the acid through a linker having a peptide chain comprising one to eight amino acids.
Il est prévu un composé d'acide hyaluronique/méthotrexate servant d'agent thérapeutique pour les maladies des articulations. Le composé d'acide hyaluronique/méthotrexate servant d'agent thérapeutique pour les maladies des articulations comprend de l'acide hyaluronique et du méthotrexate lié à un groupe carboxy de l'acide grâce à un réticulent ayant une chaîne peptide comprenant un à huit acides aminés.
Higuchi Yoshinobu
Ikeya Hitoshi
Ishizawa Takenori
Morikawa Tadashi
Okamachi Akira
Chugai Seiyaku Kabushiki Kaisha
Denki Kagaku Kogyo Kabushiki Kaisha
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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