A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01) C08B 37/08 (2006.01)
Patent
CA 2535364
The invention relates to hyaluronic acid nanoparticles for the administration of at least one active ingredient. The inventive nanoparticles comprise hyaluronic acid in salt form a positively-charged polymer, a polyanionic salt and at least one active ingredient. The method of obtaining the aforementioned nanoparticles comprises the following steps consisting in: preparing an aqueous solution of a hyaluronic acid salt, preparing an aqueous solution of a cationic polymer, adding a polyanionic salt to the solution of the hyaluronic acid salt, and stir-mixing said solutions such as to produce the nanoparticles, the active ingredient being dissolved in one of the initial solutions or in the suspension of nanoparticles obtained in order to be absorbed on the nanoparticles. The invention also relates to pharmaceutical and cosmetic compositions comprising the above-mentioned nanoparticles.
L'invention concerne des nanoparticules d'acide hyaluronique permettant d'aministrer au moins un ingrédient actif, contenant de l'acide hyaluronique sous forme de sel, un polymère positivement chargé, un sel polyanionique et au moins un ingrédient actif. L'invention concerne également un procédé d'obtention desdites nanoparticules, consistant à préparer une dissolution aqueuse d'un sel d'acide hyaluronique, à préparer une dissolution aqueuse d'un polymère cationique, à ajouter un sel polyanionique à la dissolution du sel d'acide hyaluronique, à mélanger par agitation lesdites dissolutions afin d'obtenir les nanoparticules, l'ingrédient actif étant ainsi dissous dans une desdites dissolutions ou dans la suspension des nanoparticules obtenues pour être adsorbé sur les nanoparticules. L'invention concerne également des compositions pharmaceutiques et cosmétiques contenant lesdites nanoparticules.
Alonso Fernandez Maria Jose
de La Fuente Freire Maria
Seijo Rey Maria Begona
Advanced In Vitro Cell Technologies S.l.
Advancell Advanced In Vitro Cell Technologies S.a.
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
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