Hyaluronic drug delivery system

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/127 (2006.01) A61K 38/13 (2006.01) A61K 47/36 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2266622

Pharmaceutical compositions comprising a mixture of hyaluronic acid and liposomes. Preferably, the pharmaceutical compositions further include a pharmaceutically active substance such as cyclosporin A encapsulated in the liposomes. A method for preparing a pharmaceutical composition includes producing liposomes from phospholipids, preferably in the presence of a pharmaceutically active substance (most preferably cyclosporin A) to be encapsulated within the liposomes, and mixing the liposomes with hyaluronic acid. Pharmaceutical compositions of this invention are used, for example, to topically administer pharmaceutical agents effective to treat skin disorders by deposition of that agent in the demos or sub-dermis while minimizing systemic circulation thereof. These compositions are also administered orally, parenterally and intrarectally.

L'invention concerne des compositions pharmaceutiques comprenant un mélange d'acide hyaluronique et de liposomes. De préférence, les compositions pharmaceutiques comprennent aussi une substance pharmaceutiquement active, telle que la cyclosporine A encapsulée dans les liposomes. L'invention concerne également un procédé destiné à préparer une composition pharmaceutique, consistant à produire des liposomes à partir de phospholipides, de préférence en présence d'une substance pharmaceutiquement active (idéalement de la cyclosporine A) à encapsuler à l'intérieur des liposomes, ainsi qu'à mélanger les liposomes à de l'acide hyaluronique. On utilise des compositions pharmaceutiques de la présente invention, par exemple, pour l'administration topique d'agents pharmaceutiques, efficaces dans le traitement d'affections cutanées par pénétration de cet agent dans le derme ou sous le derme, en en réduisant au minimum la circulation générale. On administre également ces compositions par voie orale, parentérale ou rectale.

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