C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) A61K 38/43 (2006.01) C12N 9/26 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2376467
The present invention relates to the isolation, purification and characterization of a hyaluronidase which derives from the tropical leech <i>Hirudinaria manillensis</i>. Therefore, according to this invention, the enzyme was called "<u>manillase</u>". The invention is furthermore concerned with the recombinant method of production of manillase which includes the disclosure of DNA and amino acid sequences as well as of expression vectors and host systems. Finally, the invention relates to the use of manillase for therapeutic purposes, for example, for the treatment of myocardial diseases, thrombotic events and tumors.
L'invention concerne l'isolation, la purification et la caractérisation d'une hyaluronidase provenant de la sangsue tropicale Hirudinaria manillensis. On a donc désigné, d'après l'invention, cette enzyme <= manillase >=. L'invention concerne, de plus, le procédé de préparation de manillase par recombinaison, ainsi que ses séquences d'ADN et d'acides aminés, ses vecteurs d'expression et ses systèmes hôtes. Elle concerne enfin l'utilisation de manillase à des fins thérapeutiques, notamment pour traiter des maladies du myocarde, des thromboses et des tumeurs.
Gardas Andrzej
Gussow Detlef
Hofmann Uwe
Kordowicz Maria
Pacuszka Tadeusz
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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