Hybrid antibodies

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/46 (2006.01) C07K 14/735 (2006.01) C07K 16/44 (2006.01)

Patent

CA 2430528

The present invention relates to binding molecules comprising (i) one or more polypeptides which form a binding site capable of binding a target molecule and (ii) an Fc effector peptide displaying one or more effector functions associated with the constant region (Fc) of an immunoglobulin heavy chain. The invention further relates to novel Fc effector peptides and nucleic acid molecules encoding said binding molecules and Fc effector peptides. The invention further relates to therapeutic uses of said binding molecules and pharmaceutical compositions containing said binding molecules.

L'invention concerne des molécules de liaison comprenant i) au moins un polypeptide formant un site de liaison capable de se lier à une molécule cible, et ii) un peptide effecteur Fc affichant au moins une fonction effectrice associée à la région constante (Fc) d'une chaîne lourde d'immunoglobuline. L'invention concerne également de nouveaux peptides effecteurs Fc et des molécules d'acide nucléique codant pour les molécules de liaison et lesdits peptides effecteurs Fc. L'invention concerne enfin les utilisations thérapeutiques desdites molécules de liaison, et des compositions pharmaceutiques contenant ces molécules de liaison.

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