Hybrid cellular receptor

Details Hybrid cellular receptor Hybrid cellular receptor

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/16 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2081771

2081771 9117252 PCTABS00008 A hybrid DNA construct comprises a first DNA sequence encoding part of the extracellular domain of a first cellular receptor and a second DNA sequence encoding part of the extracellular domain of a second cellular receptor which is specific for a different ligand than the first receptor. The hybrid receptor encoded by this DNA construct may, for instance, be used to localize the ligand-binding site of a cellular receptor or to screen for ligands or ligand antagonists.

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