Hybrid compositions for intracellular targeting

Details Hybrid compositions for intracellular targeting Hybrid compositions for intracellular targeting

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07H 21/00 (2006.01) C07K 14/425 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2272747

Hybrid compounds comprising a first domain and a second domain are provided. The first domain and the second domain are preferably covalently linked, and the first domain comprises a domain which is capable of specific binding to Gb3; and the second domain comprising a moiety selected from the group consisting of drug moiety, a nucleic acid, a probe, a polypeptide, and a hook, with the proviso that the second domain is not a verotoxin or a fragment thereof. Methods of preparing and using the hybrid compounds are also provided. Also provided are nucleic acid molecules which encode hybrid molecule of the invention, recombinant vectors including a nucleic acid molecule of the invention in a form suitable for expression of the fusion protein in a host cell, and host cells including a recombinant vector of the invention.

L'invention concerne des composés hybrides comprenant un premier domaine et un second domaine, liés de préférence par une liaison covalente. Le premier domaine comporte un domaine capable de se fixer spécifiquement sur le Gb¿3?, et le second domaine comporte un groupe fonctionnel choisi dans le groupe comprenant un groupe fonctionnel médicamenteux, un acide nucléique, une sonde, un polypeptide et un crochet, à condition que ledit second domaine ne soit pas une vérotoxine ou un de ses fragments. L'invention concerne également une méthode permettant de préparer et d'utiliser les composés hybrides. Elle concerne enfin des molécules d'acide nucléique codant pour une molécule hybride de l'invention, des vecteurs recombinants qui comportent une molécule d'acide nucléique de l'invention sous une forme convenant pour l'expression de la protéine de fusion dans une cellule hôte, et des cellules hôtes qui comportent un vecteur recombinant de l'invention.

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