Hybrid compound purification

Details Hybrid compound purification Hybrid compound purification

C - Chemistry, Metallurgy

07

K

C07K 14/55 (2006.01) C07K 1/22 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2077338

2077338 9113087 PCTABS00007 A method for purifying from a mixture a hybrid compound which contains a portion of IL-2, which portion includes at least a region of the IL-2R binding domain of IL-2, which region is effective to cause the hybrid compound to bind to cells containing an IL-2R. The method includes passing the mixture containing the hybrid compound over a column having attached thereto molecules consisting of or containing a complex sugar moiety with affinity for the hybrid compound, and eluting the hybrid compound with a suitable eluant. The invention also features related complexes of the hybrid compound and assays for the hybrid compound.

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