Hybrid cytokines

Details Hybrid cytokines Hybrid cytokines

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 1/00 (2006.01) C07K 14/52 (2006.01) C07K 14/535 (2006.01) C07K 14/54 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2116533

2116533 9305169 PCTABS00020 Hybrid cytokines containing four helical regions, each of which is derived from a corresponding .alpha.-helical region in leukemia inhibitory factor (LIF), granulocyte colony stimulating factor (G-CSF), interleukin-6 (IL-6) or oncostatin-M (OSM) are disclosed. These hybrid cytokines may further contain linking regions also derived from corresponding linking regions in these factors. The hybrid cytokines offer a unique spectrum of activities useful in treating conditions for which the native cytokines are useful or in treating conditions characterized by an excess of the native cytokines.

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