Hybrid genes for use in the production of t h-independent...

Details Hybrid genes for use in the production of t h-independent... Hybrid genes for use in the production of t h-independent...

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 35/18 (2006.01) A61K 48/00 (2006.01) C07K 14/525 (2006.01) C07K 14/54 (2006.01) C07K 14/55 (2006.01) C07K 14/57 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2159898

Recombinant vectors are provided that render the proliferative response of activated lymphocytes, particularly cytotoxic T lymphocytes, of lessened dependency on T helper cells. The vectors are comprised of a region encoding a stimulatory factor polypeptide operably linked to a heterologous transcriptional control region. Expression of the stimulatory factor polypeptide from the recombinant polynucleotide in an activated lymphocyte renders the proliferative response of less dependent on lymphocyte T helper cells. When the lymphocite is activated by binding of its cognate antigen the transcriptional control region causes transcription of the stimulatory factor encoding region. The cells containing the vector, particularly CTLs, are of use in immunotherapy.

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