Hybrid human/porcine factor viii

Details Hybrid human/porcine factor viii Hybrid human/porcine factor viii

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/37 (2006.01) C07K 14/755 (2006.01) C12N 9/64 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2133203

A hybrid human/porcine coagulation factor VIII is produced by isolation and recombination of human and porcine factor VIII subunits, or by genetic engineering of the human and porcine factor VIII genes. Subunits of factor VIII that have been puri- fied from human or porcine plasma are isolated, and hybrid human/porcine factor VIII is produced by mixing either porcine heavy chain subunits with human light chain subunits or by mixing human heavy chain subunits with porcine light chain subun- its, thereby producing human light chain/porcine heavy chain and human heavy chain/porcine light chain hybrid molecules. These hybrid molecules are isolated by ion exchange chromatography. Alternatively, recombinant DNA methods are used to swap elements of porcine factor VIII for the corresponding elements of human factor VIII to produce hybrid human/porcine fac- tor VIII.

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