Hybrid interferon/interferon tau proteins, compositions and...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/62 (2006.01) A61K 31/7056 (2006.01) A61K 38/21 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/555 (2006.01) C07K 14/56 (2006.01) C07K 19/00 (2006.01) C12N 15/09 (2006.01) C12N 15/19 (2006.01) C12N 15/21 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2454860

The present invention relates to hybrid interferon fusion proteins formed of an interferon-.alpha. protein where the C-terminal region of the interferon- .alpha. protein is replace by C-terminal region of interferon-.tau.. Also described are nucleic acid sequences encoding the interferon fusion proteins, expression vectors containing such sequences, and therapeutic applications of the interferon fusion proteins. The therapeutic applications include antiviral, anticellular proliferation, and anti-inflammatory applications. One advantage of the interferon fusion polypeptides of the present invention is that they have lower cytotoxic side effects when used to treat cells.

L'invention concerne des protéines de fusion d'interféron hybride formées d'une protéine d'interféron-.alpha. dont la région C-terminale est remplacée par la région C-terminale de l'interféron-.tau.. L'invention concerne également des séquences d'acide nucléique codant les protéines de fusion d'interféron, des vecteurs d'expression contenant de telles séquences, et des applications thérapeutiques des protéines de fusion d'interféron. Il s'agit notamment d'applications liées à la prolifération antivirale, anticellulaire et anti-inflammatoire. Ces polypeptides de fusion d'interféron présentent notamment un intérêt en ce qu'ils ont des effets cytotoxiques secondaires moindres lorsqu'on les utilise pour le traitement de cellules.

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