Hybrid matrices and hybrid matrix mixtures

Details Hybrid matrices and hybrid matrix mixtures Hybrid matrices and hybrid matrix mixtures

A - Human Necessities

61

L

A61L 27/44 (2006.01) A61K 9/00 (2006.01) A61K 48/00 (2006.01) A61L 27/24 (2006.01) A61L 27/38 (2006.01) A61L 27/54 (2006.01) C07K 14/61 (2006.01)

Patent

CA 2379971

A composition having a body of matrix material made up of insoluble collagen fibrils, and disposed therewithin: a) a plurality of vertebrate cells; b) a plurality of microcarriers; and c) an agent such as a factor that promotes vascularization, a cytokine, a growth factor, or ascorbic acid. The invention also features a method of delivering a polypeptide to an animal. The method involves introducing into the animal a fluid mixture containing: a) a population of cultured vertebrate cells genetically engineered to express the polypeptide; and b) a plurality of microcarriers.

L'invention concerne une composition présentant un corps de matière de matrice à base de fibrilles collagéniques insolubles et renfermant: a) plusieurs cellules de vertébrés, b) plusieurs microporteurs, et c) un agent tel qu'un facteur qui favorise la vascularisation, une cytokine, un facteur de croissance ou un acide ascorbique. Cette invention a également trait à une méthode d'administration d'un polypeptide à un animal consistant à introduire chez l'animal un mélange de fluides renfermant: a) une population de cellules de vertébrés de culture génétiquement modifiées en vue d'exprimer le polypeptide et b) plusieurs microporteurs.

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