Hybrid molecules

Details Hybrid molecules Hybrid molecules

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 47/48 (2006.01) C07K 14/52 (2006.01) C07K 14/55 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2035868

- 26 - Abstract of the Disclosure A hybrid molecule containing a hematopoietin receptor superfamily cytokine (or a fragment or analog thereof capable of binding to the high-affinity receptor for such cytokine) covalently bonded, at its amino terminal end, to a chemical entity which causes the hybrid molecule to be processed via a lower affinity receptor for such cytokine to a degree less than the degree of processing of the cytokine by the lower affinity receptor, provided that the chemical entity cannot be a fragment of diptheria toxin which includes the translocation domain of that toxin. APPL0685

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