Hybrid oligonucleotide phosphorothioates

Details Hybrid oligonucleotide phosphorothioates Hybrid oligonucleotide phosphorothioates

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2140649

The invention provides hybrid oligonucleotides having phosphorothioate ar phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.

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