Hybrid peptides for treatment of bacteremia and septicemia

Details Hybrid peptides for treatment of bacteremia and septicemia Hybrid peptides for treatment of bacteremia and septicemia

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/06 (2006.01) A61K 38/08 (2006.01) C07K 5/08 (2006.01) C07K 5/107 (2006.01) C07K 7/62 (2006.01) C07K 7/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2444637

Novel conjugates of bacterial outer membrane binding peptides, preferably having bacterial sensitization activity, and immune cells chemotactic peptides, and pharmaceutical compositions containing same useful in the treatment of bacteremia and/or septicemia following infection by gram negative bacteria administered alone or in combination with conventional antibiotics.

L'invention concerne de nouveaux conjugats de peptides de liaison à la membrane extérieure d'une bactérie présentant, de préférence, une activité de sensibilisation bactérienne. L'invention traite aussi de peptides chimiotactiques de cellules immunitaires, et de compositions pharmaceutiques contenant ces composés et permettant de traiter la bactériémie, et/ou la septicémie suivant une infection par des bactéries gram négatives lors de leur administration seules ou en association avec des antibiotiques traditionnels.

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