Hybrid polypeptides with selectable properties

Details Hybrid polypeptides with selectable properties Hybrid polypeptides with selectable properties

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01)

Patent

CA 2617649

The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, such as diabetes and diabetes-related conditions. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.

L'invention concerne généralement de nouveaux polypeptides hybrides sélectionnables servant d'agents pour le traitement et pour la prévention de maladies et de troubles métaboliques pouvant être soulagés par le contrôle des taux de glucose dans le plasma, des taux d'insuline, et/ou de la sécrétion d'insuline, notamment les diabètes et les troubles associés à ces diabètes. De tels troubles et de tels états pathologiques comprennent, de manière non exhaustive, l'hypertension, la dyslipidémie, les maladies cardio-vasculaires, les troubles alimentaires, la résistance à l'insuline, l'obésité et le diabète sucré, et tous les types de diabètes gestationnels, ainsi que les diabètes de type 1 et de type 2.

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