Hybrid protein and fused gene encoding gene

Details Hybrid protein and fused gene encoding gene Hybrid protein and fused gene encoding gene

C - Chemistry, Metallurgy

12

N

530/13, 195/1.23

C12N 15/62 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01) C07K 14/245 (2006.01) C07K 14/25 (2006.01) C07K 14/28 (2006.01) C07K 14/34 (2006.01) C07K 14/415 (2006.01) C07K 14/55 (2006.01) C07K 14/575 (2006.01) C12N 9/02 (2006.01) C12N 9/24 (2006.01) C12N 15/70 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 1339359

A fused gene encoding a hybrid protein, the fused gene including a first sequence encoding a fragment of the diphtheria toxin molecule which renders the hybrid protein capable of penetrating the cytoplasmic membrane of a cell and incapable of killing the cell, fused to a second sequence encoding a portion of a polypeptide ligand effective to enable the hybrid protein to bind selectively to the cell. The invention provides for labelling of targeted cells for diagnostic purposes.

483407

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