Hybrid protein comprising t-helper cell stimulating epitopes...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 39/118 (2006.01) C07K 14/295 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01) G01N 33/569 (2006.01) G01N 33/571 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2228522

A recombinant hybrid protein is disclosed which expresses at least one chlamydial B-cell neutralizing antibody stimulating epitope and one chlamydial T-helper cell epitope, and is capable of inducing antibodies immunoreactive with Chlamydia trachomatis in vertebrate. Also disclosed is a nucleic acid molecule comprising at least a portion encoding the recombinant hybrid protein and an antibody immunoreactive with C. trachomatis producible by immunizing a host with an immunogenic component comprising the recombinant hybrid protein or the nucleic acid molecule and a carrier. The present invention relates to recombinant hybrid proteins, containing both B and T-helper cell epitopes which can be used in vaccines to provide a protective response to C. trachomatis serovars.

Protéine hybride de recombinaison qui exprime au moins un épitope de stimulation d'anti-corps neutralisant lymphocytes B chlamydiales et un épitope de lymphocyte T inducteur de chlamydia, cette protéine étant capable d'induire des anti-corps immunoréactifs avec chlamydia trachomatis chez les vertébrés. L'invention porte également sur une molécule d'acide nucléique renfermant au moins une partie codant la protéine hybride de recombinaison et un anti-corps immunoréactif avec chlamydia trachomatis, cette molécule pouvant être produite par immunisation d'un hôte à l'aide d'un composant immunogénique renfermant la protéine hybride de recombinaison ou la molécule d'acide nucléique et un porteur. L'invention porte enfin sur des protéines hybrides de recombinaison renfermant à la fois des épitopes de lymphocytes B et de lymphocytes T auxiliaires pouvant être utilisés dans des vaccins pour obtenir une réaction de protection à des sérovars de chlamydia trachomatis.

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