Hybrid proteins of active-site serine beta-lactamase

Details Hybrid proteins of active-site serine beta-lactamase Hybrid proteins of active-site serine beta-lactamase

C - Chemistry, Metallurgy

12

N

C12N 9/86 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) C07K 14/245 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2555393

The present invention refers to a recombinant nucleotide sequence which codes upon expression for at least a part of a bifunctional hybrid active-site serine .beta.-~lactamase protein, wherein the .beta.-lactamase protein is bearing at least one heterologous sequence, wherein in that the hybrid protein is having two functions, the first function is associated with the .beta.- lactamase portion and the second function is associated with the heterologous sequence having a biological function which is different from the first function.

La présente invention se rapporte à une séquence nucléotidique recombinée, qui, lorsqu'elle est exprimée, code au moins une partie d'une protéine de .beta.-lactamase à sérine active hybride bifonctionnelle, ladite protéine de .beta.-lactamase portant au moins une séquence hétérologue. La protéine hybride est caractérisée en ce qu'elle est dotée de deux fonctions, la première étant associée à la partie .beta.-lactamase, et la seconde étant associée à la séquence hétérologue dotée d'une fonction biologique différente de la première fonction.

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