Hybrid proteins which form heterodimers

Details Hybrid proteins which form heterodimers Hybrid proteins which form heterodimers

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/22 (2006.01) A61K 38/24 (2006.01) A61K 47/48 (2006.01) C07K 14/575 (2006.01) C07K 14/59 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2245877

A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-.beta. and TPO, linked to a subunit of a heterodimeric proteinaceous hormone, such as hCG. Each coexpressed sequence contains a corresponding hormone subunit so as to form a heterodimer upon expression. Corresponding DNA molecules, expression vectors and host cells are also disclosed as are pharmaceutical compositions and a method of producing such proteins.

Protéine hybride comprenant deux séquences d'acides aminés exprimées conjointement et constituant un dimère. Chaque séquence contient la partie de fixation d'un récepteur, tel que TBP1 ou TBP2, ou un ligand, tel que IL-6, IFN-.beta. et TPO, lié à une sous-unité d'une hormone protéique hétérodimère, telle que hCG. Chaque séquence exprimée conjointement contient une sous-unité d'hormone correspondante, de manière à constituer un hétérodimère lors de l'expression. L'invention concerne également des molécules correspondantes d'ADN, des vecteurs d'expression et des cellules hôtes, ainsi que des compositions pharmaceutiques et un procédé de préparation de ces protéines.

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