C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C12N 5/07 (2010.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07K 14/475 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 17/02 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12N 15/18 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2455830
Polypeptides of the neuregulin (NRG) heparin binding domain (N-HBD) and nucleic acids coding therefor are disclosed. In particular, fusion polypeptides are produced that comprise, as a targeting structure, a N-HBD polypeptide, fragment, homologue or functional derivative and a protein to be targeted. This is fused to a polypeptide or peptide being targeted (Ptrg) to cell surfaces rich in heparan sulfate proteoglycans to either activate or inhibit interactions at tyrosine kinase receptors. Such products are used to treat diseases or conditions where either agonism or antagonism at tyrosine kinase receptors has beneficial effects, including cancer and a multitude of diseases of the nervous system.
L'invention concerne des polypeptides du domaine se liant à l'héparine (N-HBD) de neuréguline (NRG) et des acides nucléiques les codant. En particulier, des polypeptides de fusion, qui sont produits, comportent, comme structure de ciblage, un polypeptide N-HBD, un fragment, un homologue ou un dérivé fonctionnel et une protéine à cibler fusionnant à un polypeptide ou peptide ciblant (P¿trg?) des surfaces cellulaires riches en protéoglycanes de sulfate d'héparane afin d'activer ou d'inhiber des interactions au niveau des récepteurs de tyrosine kinase. De tels produits servent dans le traitement de maladies ou d'états où l'agonisme ou l'antagonisme au niveau des récepteurs de tyrosine kinase présente des effets bénéfiques, notamment dans le cas des cancers et de nombreuses maladies du système nerveux.
Smart & Biggar
Wayne State University
LandOfFree
Hybrid proteins with neuregulin heparin-binding domain for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Hybrid proteins with neuregulin heparin-binding domain for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hybrid proteins with neuregulin heparin-binding domain for... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1582424