Hybrid qa molecules wherein q is an aminoquinoline and a is...

Details Hybrid qa molecules wherein q is an aminoquinoline and a is... Hybrid qa molecules wherein q is an aminoquinoline and a is...

C - Chemistry, Metallurgy

07

D

C07D 499/76 (2006.01) A61K 31/4709 (2006.01) A61P 31/04 (2006.01) C07D 215/56 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 499/48 (2006.01) C07D 499/54 (2006.01) C07D 499/64 (2006.01) C07D 501/00 (2006.01) C07D 501/34 (2006.01) C07K 5/00 (2006.01)

Patent

CA 2572442

The invention concerns an aminoquinoline-antibiotic hybrid compound of general formula (I): Q-(Y1)p-(U)p'-(Y2)p''-A; wherein Q represents an aminoquinoline, (Y1)p-(U)p'-(Y2)p'' is an optional spacer and A is an antibiotic residue. The invention enables the antibiotic residue activity to be unexpectedly enhanced.

L'invention concerne un composé hybride aminoquinoléine-antibiotique défini par la formule générale (I) : Q - (Y1)p - (U)p' - (Y2)p'' - A ; dans laquelle Q représente une aminoquinoléine, (Y1)p - (U)p' - (Y2)p'' - est un bras espaceur éventuel et A est un résidu antibiotique. L'invention permet d'améliorer de manière inattendue l'activité du résidu antibiotique.

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