Hybrid recombinases for genome manipulation

Details Hybrid recombinases for genome manipulation Hybrid recombinases for genome manipulation

A - Human Necessities

61

K

A61K 38/16 (2006.01) C07K 19/00 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2562552

The present invention provides methods to site-specifically manipulate genomes by using hybrid recombinases. Hybrid recombinases comprise a modified catalytic domain from a unidirectional serine phage integrase, fused to a foreign DNA recognition domain.

La présente invention concerne des procédés permettant la manipulation site-spécifique de génomes par l'utilisation de recombinases hybrides. Les recombinases hybrides comprennent un domaine catalytique modifié provenant d'une serine phage intégrase unidirectionnelle fusionnée avec un domaine de reconnaissance d'ADN étranger.

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