Hybrid viral plasmid and microorganisms containing same

Details Hybrid viral plasmid and microorganisms containing same Hybrid viral plasmid and microorganisms containing same

C - Chemistry, Metallurgy

12

N

195/1.14, 195/1.

C12N 1/20 (2006.01) C12N 15/00 (2006.01) C12N 15/86 (2006.01)

Patent

CA 1215332

ABSTRACT pML BK is a hybrid plasmid which is constructed of pML which contains the entire nucleotide sequence of the plasmid pBR322 except for deletion of nucleotide sequences 1120-2490 bp and 0 to 375 bp, and BK which contains the entire nucleotide sequence of the Gardner strain of BK virus except for deletion of nucleotide sequences between bp 5089-5196. Into the pML BK plasmid may be inserted a viral or human gene X to be expressed, an example of which is TK which represents the Bam HI generated 3,600 bp DNA fragmement of herpes simplex virus type 1 which contains the herpes simplex virus type 1 TK DNA. The majority of the pML BK X DNA molecules remain in the episomal or free state in the human cells 143B and express the gene X.

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