Hybrid with interferon-.alpha. and an immunoglobulin fc...

Details Hybrid with interferon-.alpha. and an immunoglobulin fc... Hybrid with interferon-.alpha. and an immunoglobulin fc...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/21 (2006.01) A61K 47/48 (2006.01) A61P 37/04 (2006.01) C07K 14/555 (2006.01) C07K 14/56 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2239522

Disclosed is a hybrid recombinant protein consisting of human interferon, preferably interferon-.alpha. (IFN.alpha.), and human immunoglobulin Fc fragment, preferably .gamma.4 chain, joined by a peptide linker comprising the sequence Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser (SEQ ID NO:1).

L'invention concerne une protéine hybride de recombinaison composée d'interféron humain, de préférence interféron-.alpha. (IFN.alpha.), et d'un fragment Fc d'immunoglobuline humaine, de préférence à chaîne .gamma.4, la liaison entre les deux étant assurée par un segment de liaison peptidique qui comprend la séquence Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser (SEQ ID NO:1).

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