C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2198261
The oligoribonucleotide analogs of the invention, as exemplified in the figure, are relatively small, three-dimensional structures derived from larger parental RNA molecules. The analogs include a first nucleic acid structure including one or more nucleotide sequences that are derived from a region of parental RNA, wherein in its native state, the region binds to a ligand, e.g., an aminoglycoside, with a parental RNA ligand binding pattern, and a second nucleic acid structure including one or more nucleotide sequences combined with the first nucleic acid structure to form the analog and provide the analog with a conformation that binds the ligand with a ligand binding pattern that is substantially identical to the parental RNA ligand binding pattern. These analogs can be used to identify novel therapeutic compounds.
Les analogues oligoribonucléotidiques de l'invention, tels que présentés en figure 6, sont des structures tridimensionnelles relativement petites, dérivées de molécules d'ARN parental plus grosses. Ces analogues comportent une première structure d'acide nucléique renfermant au moins une séquence nucléotidique dérivée d'une région de l'ARN parental. A son état natif, cette région se lie à un ligand, tel qu'un aminoglycoside, selon un modèle de liaison de ligand d'ARN parental, et une seconde structure d'acide nucléotidique renfermant au moins une séquence nucléotidique combinée à la première structure d'acide nucléique afin de produire l'analogue et de donner à celui-ci une configuration qui lie le ligand selon un modèle de liaison de ligand pratiquement identique au modèle de liaison du ligand de l'ARN parental. Ces analogues peuvent être utilisés pour identifier de nouveaux composés thérapeutiques.
Purohit Prakash
Stern Seth
Smart & Biggar
University Of Massachusetts Medical Center
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