Hybridomas that undergo class-switching in vitro

Details Hybridomas that undergo class-switching in vitro Hybridomas that undergo class-switching in vitro

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C07K 16/00 (2006.01) C12N 5/16 (2006.01) C12N 15/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2751621

The present invention provides fully human antibodies in a transgenic animal of a desired isotype in response to immunization with virtually any desired antigen. The human immunoglobulin heavy chain transgene in the foregoing animals comprises a human constant region gene segment comprising exons encoding the desired heavy chain isotype, operably linked to switch segments from a constant region of a different heavy chain isotype, i.e., a non-cognate switch region. In the transgenes of the invention, the non-cognate switch region may be a switch region from a different species than the constant region coding segment. The invention further provides a DNA vector and method for the production of hybridomas that undergo class-switching in vitro. The DNA vector of the invention comprises a loxP site and DNA encoding a constant region gene.

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