Hydantion derivatives as inhibitors of matrix...

Details Hydantion derivatives as inhibitors of matrix... Hydantion derivatives as inhibitors of matrix...

C - Chemistry, Metallurgy

07

D

C07D 491/10 (2006.01) A61K 31/4164 (2006.01) A61K 31/4166 (2006.01) A61K 31/438 (2006.01) A61K 31/4709 (2006.01) A61K 45/06 (2006.01) A61P 29/00 (2006.01) C07D 233/76 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/10 (2006.01) C07D 487/10 (2006.01)

Patent

CA 2447475

The present application describes novel hydantoin derivatives of formula (I), or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R5, R6, R7, R11, and n are defined in the present specification, which are useful as inhibitors of matrix metallproteinases (MMP), TNF-.alpha. converting enzyme (TACE), aggrecanase, or a combination thereof.

L'invention concerne de nouveaux dérivés d'hydantoïne représentés par la formule (I) : (I) ou leurs formes sel ou promédicament pharmaceutiquement acceptables. A, B, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?11¿, et n sont définis dans le descriptif. Ces dérivés, sels ou promédicaments sont utiles en tant qu'inhibiteurs des métalloprotéinases matricielles (MMP), de l'enzyme de conversion du TNF-.alpha. (TACE), de l'agrécanase ou d'une combinaison de ceux-ci..

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