Hydantoin compounds and method

Details Hydantoin compounds and method Hydantoin compounds and method

C - Chemistry, Metallurgy

07

D

260/315.05

C07D 233/72 (2006.01) C07D 233/74 (2006.01) C07D 235/02 (2006.01)

Patent

CA 1064505

ABSTRACT Hydantoin derivatives of varying lipophilic character, and having the general formula Image wherein R1 and R3 may be the same or different end are lower alkyl, lower hydroxyalkyl, -H, phenyl, or R1 an R3 together are -CH3(CH3)nCH2- where n = 2 or 3, and R1 and R3 are different when R1 or R3 is phenyl, were prepared as nitrogen mustard carriers for central nervous system anti-tumor evaluation. Activity was studied in the murine ependymoblastoma brain tumor system. Multiple cures were observed for three of the four analogs examined. The compounds were also active in the intraperitoneal luekemia L1210 and P388 systems as well as in B16 melanoma and Lewis lung carcinoma.

257806

Affiliated with

Also associated with

Rating

Hydantoin compounds and method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hydantoin compounds and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hydantoin compounds and method will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-270210