C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61K 31/4188 (2006.01) A61K 31/437 (2006.01) A61K 31/4725 (2006.01) A61K 31/4985 (2006.01) A61P 1/02 (2006.01) A61P 1/04 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 17/02 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 37/00 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2436943
Compounds having the formula (I): [chemical drawing] and pharmaceutically- acceptable salts thereof, are useful for treating inflammatory or immune diseases, in which A is a four to seven membered heterocyclic or carbocyclic saturated ring; L and K are O or S; M is N or CH; Y is N or CH; Z is hydrogen, alkyl or substituted alkyl; and R1-R4 are as defined in the specification.
L'invention concerne des composés représentés par la formule (I): et des sels pharmaceutiquement acceptables de ceux-ci, utiles pour traiter des maladies inflammatoires ou immunes. Dans la formule, A représente un noyau saturé carbocyclique ou hétérocyclique comprenant de quatre à sept ramifications; L et K représentent O ou S; M représente N ou CH; Y représente N ou CH; Z représente hydrogène, alkyle ou alkyle substitué; et R1-R4 sont tels que définis dans la description.
Dhar Murali T.g.
Iwanowicz Edwin J.
Launay Michele
Maillet Magali Jeannine Blandine
Nicolai Eric Antoine
Bristol-Myers Squibb Pharma Company
Cerep Sa
Gowling Lafleur Henderson Llp
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