Hydantoin derivatives

Details Hydantoin derivatives Hydantoin derivatives

C - Chemistry, Metallurgy

07

K

C07K 5/023 (2006.01) A61K 38/06 (2006.01) C07D 233/76 (2006.01) C07D 233/96 (2006.01) C07K 5/02 (2006.01) C07K 5/078 (2006.01) C07K 5/09 (2006.01) C07K 5/097 (2006.01) C07K 5/11 (2006.01) C07K 5/117 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2075590

The invention relates to compounds of the formula I Image in which R1 represents, for example, -(CH2)n-NH-X or -CH2-C6H4-NH- X, wherein n is an integer from 3 to 5 and X represents, for example, hydrogen or C1-C6-alkyl, R2 denotes hydrogen or C1-C6- alkyl, R3 denotes hydrogen or a phenyl radical, R4 denotes, for example, hydrogen and Y denotes, for example, -(CH2)m-CO-, wherein m represents an integer from 1 to 4. The compounds of the invention inhibit platelet aggregation, formation of metastases and binding of osteoclasts to the bone surfaces. They are therefore useful for the prevention of arteriosclerosis, thrombosis and osteoporosis and prophylactically against cancer.

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