Hydantoin derivatives and their use as tace inhibitors

Details Hydantoin derivatives and their use as tace inhibitors Hydantoin derivatives and their use as tace inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/47 (2006.01) A61P 43/00 (2006.01) C07D 233/76 (2006.01) C07D 235/02 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 413/12 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2497571

Hydantoin derivatives of Formula (1) that are useful in the inhibition of metalloproteinases and in particular in the inhibition of TNF-.alpha. Converting Enzyme (TACE).

L'invention concerne des dérivés de l'hydantoïne de formule (1) que l'on utilise dans l'inhibition des métalloprotéinases et plus particulièrement dans l'inhibition de l'enzyme TACE <= TNF-.alpha. Converting Enzyme >=.

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