Hydantoin derivatives, process for producing the same and...

Details Hydantoin derivatives, process for producing the same and... Hydantoin derivatives, process for producing the same and...

C - Chemistry, Metallurgy

07

D

167/208, 260/305

C07D 491/107 (2006.01) A61K 31/395 (2006.01) C07D 491/10 (2006.01) C07D 491/20 (2006.01)

Patent

CA 1249271

ABSTRACT OF THE DISCLOSURE 1-Substituted-spiro[chroman-4,4'-imidazolidine]- 2',5'-dione compounds are useful for treating anti- arrhythmia and have the formula: Image (wherein: X1 and x2 are each hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, trifuloroethoxy or nitro or together form alkylenedioxy; R1 and R2 are each hydrogen or alkyl or together form cycloalkyl; Image R3 and R4 are each hydrogen, alkyl, hydroxyalkyl or aralkyl or together with the nitrogen atom form saturated heterocyclic group; R5 and R6 are each hydrogen, phenyl or OR7 (R7 is hydrogen, acyl, alkyl or aralkyl) or together with the carbon atom form 4-or 5-membered cyclic group containing two oxygen atoms or R5 and R6 together form =O; and n is 2 to 7).

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