C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/444 (2006.01) A61P 1/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2641713
The anti-angiogenic drug AMG 706 is provided in the mono-phosphate hydrate form. Also provided is AMG 706 drug substance wherein the AMG 706 is present, in at least a detectable amount, as AMG 706 phosphate dihydrate. Also provided are processes for preparing AMG 706 phosphate dihydrate, AMG 706 drug substance of the invention, and a pharmaceutical composition of the invention. Also provided is a method of treating a medical condition or disorder in a subject where treatment with an anti-angiogenic is indicated, comprising administering, for example orally, a composition of the invention in a therapeutically effective amount.
L'invention concerne un médicament anti-angiogénique AMG 706 sous forme d'hydrate de monophosphate. Elle concerne aussi une substance médicamenteuse AMG 706 où ledit AMG 706 est présent au moins en quantité détectable, sous forme de dihydrate de phosphate d'AMG 706. Elle concerne aussi des procédés de préparation du dihydrate de phosphate d'AMG 706, d'une substance médicamenteuse AMG 706 selon l'invention et d'une composition pharmaceutique selon l'invention. Elle concerne aussi une méthode pour traiter une condition ou un trouble médical chez un sujet pour lequel un traitement anti-angiogénique est indiqué, comprenant l'administration, par exemple orale, d'une composition selon l'invention en quantité thérapeutiquement efficace.
Alva Gonzalo
Neervannan Seshadri
Amgen Inc.
Gowling Lafleur Henderson Llp
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