Hydratropic acid derivatives and process for the production...

Details Hydratropic acid derivatives and process for the production... Hydratropic acid derivatives and process for the production...

C - Chemistry, Metallurgy

07

C

260/278, 260/316

C07C 65/00 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/475 (2006.01) C07C 59/68 (2006.01) C07C 59/72 (2006.01) C07C 69/76 (2006.01) C07D 207/325 (2006.01) C07D 209/44 (2006.01) C07D 211/46 (2006.01) C07D 215/06 (2006.01) C07D 215/14 (2006.01) C07D 295/096 (2006.01) C07D 295/14 (2006.01)

Patent

CA 1059516

ABSTRACT OF THE DISCLOSURE Hydratropic acid derivatives of the formula Image wherein R1 is H, alkyl of 1-4 carbon atoms, 2-acetamidoethyl, 1-methyl-4-piperidyl, or 2,3-dihydroxypropyl, and R2 is Hal, phenyl, 4-Hal-phenyl, 4-Hal-phenoxy, 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, 1-pyrryl, piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1,2,3,4-tetrahydro-4-quinolyl or 1-methyl-1,2,3,4-tetrahydro-4-quinolyl, Hal being F, Cl, or Br, and the physiologically acceptable salts thereof, which possess cholesterol and triglyceride serum-level-lowering activity, can be prepared by reacting a phenol of the formula Image with a compound of the formula X-C(CH3)(C6H5)-COOR1 wherein X represents Cl, Br, I, OH, or esterified OH.

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