Hydraulic surgical cement

Details Hydraulic surgical cement Hydraulic surgical cement

A - Human Necessities

61

K

A61K 6/033 (2006.01) A61L 24/00 (2006.01) A61L 24/02 (2006.01) A61L 27/00 (2006.01) A61L 27/12 (2006.01) A61L 27/46 (2006.01) A61L 27/54 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2306562

The cement for surgical purposes comprises three components. The first component comprises beta tertiary calciumphosphate .beta.-Ca3(PO4)2 (.beta.-TCP) particles; and monocalcium phosphate Ca(H2O4)2 (MCPA) or monocalcium phosphate monohydrate Ca(H2PO4).H2O (MCPM) particles or phosphoric acid. The second component comprises water. The third component comprises particles having an average diameter which is larger than the average diameter of said beta tertiary calciumphosphate .beta.-Ca3(PO4)2 (.beta.-TCP) particles of said first component. Upon mixing of said three components a hardened mass comprising brushite CaHPO4. 2H2O (DCPD) is formed. The .beta.-TCP particles have a specific surface area of less than 10,000 m2/g and a Ca/P atomic ratio different from 1,50. The component constitutes 1 to 99 volume-percent of said hardened mass. The cements according to the invention may be used in dental and maxillofacial surgery (alveolar ridge reconstruction, dental socket filling), for orthopaedic applications (bone fracture repair, bone augmentation) and for local drug delivery (antibiotics, anti-inflammatory and anti-cancer drugs).

L'invention concerne un ciment destiné à être utilisé en chirurgie et constitué de trois composants. Le premier de ces composants renferme des particules de bêta-phosphate tricalcique beta -Ca3(PO4)2 ( beta -TCP), des particules de phosphate monocalcique Ca(H2PO4)2 (MCPA) ou de monohydrate de phosphate monocalcique Ca(H2PO4)2.H2O (MCPM), ou de l'acide phosphorique. Le second composant renferme de l'eau, et le troisième contient des particules dont le diamètre moyen est supérieur au diamètre moyen desdites particules de bêta-phosphate tricalcique beta -Ca3(PO4)2 ( beta -TCP) du premier composant. On mélange ces trois composants de manière à former une masse durcie renfermant de la brushite CaHPO4.2H2O (DCPD). Les particules de beta -TCP présentent une aire spécifique inférieure à 10 000 m<2>/g et un rapport atomique Ca/P différent de 1,50, le composant représentant 1 à 99 pour cent en volume de ladite masse durcie. Les ciments fabriqués selon cette invention peuvent être utilisés en chirurgie dentaire et maxillo-faciale (restauration d'arêtes alvéolaires, obturation d'alvéoles dentaires), ainsi que dans des applications orthopédiques (réparation de fractures osseuses, croissance osseuse) et d'apport local de médicaments (médicaments antibiotiques, anti-inflammatoires, et anticancéreux).

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