Hydrazide derivatives as prostaglandin receptors modulators

Details Hydrazide derivatives as prostaglandin receptors modulators Hydrazide derivatives as prostaglandin receptors modulators

C - Chemistry, Metallurgy

07

C

C07C 243/28 (2006.01) A61K 31/16 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2529123

The present invention relates to hydrazide derivatives of Formula (I) notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such hydrazide derivatives. Said hydrazide derivatives are useful in the treatment of preterm labor, dysmenorrhea, fertility disorders, asthma, hypertension, undesired blood clotting, preelampsia, eclampsia, an eosinophil disorder, undesired bone loss, renal dysfunction, an immune deficiency disorder, ichthyosis, elevated intraocular pressure, infertility, sexual dysfunction, gastric ulcers and inflammatory disorders.

L'invention concerne des dérivés d'hydrazides de formule (I) destinés à être utilisés en particulier comme composés pharmaceutiquement actifs, ainsi que des formulations pharmaceutiques contenant ces dérivés d'hydrazides. Lesdits dérivés d'hydrazides sont utiles en traitement des troubles et états suivants : accouchement prématuré, dysménorrhée, troubles de la fertilité, asthme, hypertension, coagulation sanguine indésirable, prééclampsie, éclampsie, trouble éosinophilique, perte osseuse indésirable, dysfonctionnement rénal, trouble d'immunodéficience, ichtyose, pression intraoculaire élevée, infertilité, dysfonction sexuelle, ulcères gastriques et troubles inflammatoires.

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