Hydrazine-based and carbonyl-based bifunctional crosslinking...

Details Hydrazine-based and carbonyl-based bifunctional crosslinking... Hydrazine-based and carbonyl-based bifunctional crosslinking...

C - Chemistry, Metallurgy

07

D

C07D 207/46 (2006.01) C07H 21/00 (2006.01) C07K 1/107 (2006.01) C07K 17/06 (2006.01) C07K 17/14 (2006.01) C08G 65/333 (2006.01) C08J 3/24 (2006.01) C08H 1/00 (2006.01)

Patent

CA 2391316

Reagents and methods are provided for crosslinking and immobilizing biomolecules, drugs and synthetic polymers. The reagents possess (i) a thiol or amino reactive group; and (ii) a hydrazino or oxyamino moiety. Conjugates and immobilized biomolecules are also provided.

L'invention concerne des réactifs et des méthodes de réticulation et d'immobilisation de biomolécules, de médicaments et de polymères synthétiques. Les réactifs possèdent: i) un groupe réactif thiol ou amino; et ii) un groupe fonctionnel hydrazino ou oxyamino. L'invention concerne en outre des conjugués ainsi que des biomolécules immobilisées.

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