Hydrazine containing conjugates of polypeptides and...

Details Hydrazine containing conjugates of polypeptides and... Hydrazine containing conjugates of polypeptides and...

C - Chemistry, Metallurgy

12

N

C12N 9/96 (2006.01) A61K 47/48 (2006.01) C07K 17/08 (2006.01) C12N 11/02 (2006.01)

Patent

CA 2101918

2101918 9216555 PCTABS00016 Biologically active macromolecular conjugates of a biologically active polypeptide or glycopolypeptide and one or more water-soluble polymer molecules covalently bonded thereto at a reactive carbonyl or carboxylic acid group of a peptide moiety on the polypeptide or glycopolypeptide or at an oxidized carbohydrate moiety of the glycopolypeptide by a linkage containing a hydrazide or hydrazone functional group. The linkage preferably also includes an amino acid or a peptide sequence.

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