C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07B 61/00 (2006.01)
Patent
CA 2410466
The present invention relates to hydrazinyl and nitrogen oxide pyrazoles of the formula I: <see formula I> wherein the ring of the formula (R5)-A-(SO mR4) is a substituted pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazolyl or phenyl; m is 0, 1 or 2; R1 is H, nitro, cyano, alkyl, alkylsulfonyl, arylsulfonyl, formyl, ketone, ester or amino; R2 is H, nitro, cyano, hydrocarbon, heteroaryl, heterocyclyl, alkoxy, cycloalkyloxy, aryloxy, heteroaryloxy, heterocyclyloxy, formyl, aryloxy, ketone, ester, amino, substituted amide or alkylthio; R3 is substituted hydrazinyl or substituted nitrogen oxide; R4 is optionally substituted amide, amino, imine or alkyl; and R5 is H, halo, alkyloxy, hydrocarbon, cyano, formyl, ketone, ester, amide, amino, alkylthio or alkyl. The present invention also relates to pharmaceutical compositions containing compounds of formula I and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.
Rast Bryson
Sakya Subas Man
Pfizer Products Inc.
Smart & Biggar
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