Hydrazoadenosines

Details Hydrazoadenosines Hydrazoadenosines

C - Chemistry, Metallurgy

07

H

C07H 19/16 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2093502

The present invention discloses a compound of the formula: (see formula one) where R1 is hydrogen or the group -C(R3)(R5)-R4, where R3 and R4 are the same or different and are hydrogen, C1 to C12 linear or branched alkyl, C3 to C7 cycloalkyl, C6 to C10 aryl unsubstituted or substituted with C1 to C6 linear or branched alkyl, C1 to C6 linear or branched alkoxy, nitro, amino, amino substituted with at least one C1 to C6 linear or branched alkyl or phenyl, C2 to C10 aralkyl, C4 to C8 heteroaryl wherein said heteroatom is nitrogen, phosphorous, sulfur or oxygen, and R2 is hydrogen, or taken together with R5, forms a chemical bond, and R is a monosaccharide radical selected from the group consisting essentially of glucose, fructose, ribose, 2-deoxyribose, mannose, galactose, xylose and arabinose. The compounds prepared by the present invention are therapeutically effective adenosine receptor agonists in mammals. Thus, they are effective for treating conditions which respond to selective adenosine A2 receptor stimulation (particularly adenosine-2). Accordingly, the compounds of the present invention are useful for treating hypertension, thrombosis and atherosclerosis and for causing coronary vasodilation.

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