Hydrazone and oxime derivatives of pyrrolidine as...

Details Hydrazone and oxime derivatives of pyrrolidine as... Hydrazone and oxime derivatives of pyrrolidine as...

C - Chemistry, Metallurgy

07

D

C07D 207/09 (2006.01) A61K 31/40 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2395202

Compounds having the formula (I) that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

La présente invention concerne des composés représentés par la formule I, qui sont des inhibiteurs sélectifs et efficaces de PDE4, de même que des techniques de préparation de ceux-ci. Cette invention concerne aussi l'utilisation de ces composés dans le traitement de maladies inflammatoires et d'autres maladies dans lesquelles des niveaux de cytokines élevés sont en cause, ainsi que des troubles du système nerveux central.

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