C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/00 (2006.01) A61K 31/15 (2006.01) A61P 25/00 (2006.01) C07D 233/00 (2006.01)
Patent
CA 2579472
The invention relates to compounds having the general formula (I) wherein R3 is selected from the group consisting of H, methyl and hydroxyalkyl, and wherein Z1 and Z2are selected independently from one another from the group consisting of substituted or un~substituted phenyl, naphtyl, pyridinyl, pyrazolyl, pyramidinyl, pyrazidinyl, quinolinyl, iso-quinolinyl, coumarinyl, indolyl, thiazolyl and thiophenyl groups bearing substituents n R1 and m R2,wherein R1 and R2 which may be the same or are different from one another are selected from the group consisting of H, alkyl, cycloalkyl, -C02R4, - CONHR4, -CR4O, -SO2R4, -NR4-CO-R4, alkoxy, al~kylthio, -OH, -O-aryl, -O- cycloalkyl, -S-aryl, -S-cycloalkyl, hy~droxyalkyl, halogen, haloalkyl, haloalkoxy, -CN, -NO2, hydroxyal~ kylamine, aminoalkyl, alkylamine, aryl, heteroaryl and sulfona~mide, wherein R4 is selected from the group consisting of H, C1 to C6 branched or unbranched alkyl, aryl, cycloalkyl, alkoxy, hetero~cycloalkyl, -OH, -O-aryl, -O-alkyl, -O-cycloalkyl, aminoalkyl, alkylamine, aryl and heteroaryl, and wherein n and m are the num~bers of the substituents R1 and R2 in Z1 and Z2,respectively, which are in a range between 0 and 5, with the proviso that if n and m are integers higher than 2, R1 and/or R2may form a fused aromatic or a carbocyclic or heterocyclic ring system, or a salt, or a physiologically functional derivative, or a prodrug thereof.
L'invention porte sur des composés de la formule générale (1) dans laquelle R3 est choisi dans le groupe composé de H, méthyle et hydroxyalkyle, et dans laquelle Z1 et Z2sont choisis indépendamment l'un de l'autre dans le groupe composé de groupes phényle, naphtyle, pyridinyle, pyrazolyle, pyramidinyle, pyrazidinyle, quinolinyle, iso-quinolinyle, coumarinyle, indolyle, thiazolyle et thiophényle substitués ou non substitués, portant les substituants n R1 et m R2,où R1 et R2, qui peuvent être les mêmes ou différents, sont choisis dans le groupe composé de H, alkyle, cycloalkyle, -C02R4, -CONHR4, -CR4O, -SO2R4, -NR4-CO-R4, alcoxy, alkylthio, -OH, -O-aryle, -O-cycloalkyle, -S-aryle, -S-cycloalkyle, hydroxyalkyle, halogène, haloalkyle, haloalcoxy, -CN, -NO2, hydroxyalkylamine, aminoalkyle, alkylamine, aryle, hétéroaryle et sulfonamide, où R4 est choisi dans le groupe composé de H, alkyle C1 à C6 ramifié ou non ramifié, aryle, cycloalkyle, alcoxy, hétérocycloalkyle, -OH, -O-aryle, -O-alkyle, -O-cycloalkyle, aminoalkyle, alkyleamine, aryle et hétéroaryle, et où n et m représentent les nombres de substituants R1 et R2 dans Z1 et Z2,respectivement, qui sont compris dans une plage de 0 à 5, à condition que si n et m sont des entiers supérieurs à 2, R1 et/ou R2 peuvent former un noyau aromatique fusionné ou un noyau carbocyclique ou hétérocyclique, ou un sel, ou un dérivé physiologiquement fonctionnel ou un promédicament de ces derniers.
Brigo Alessandro
Garcia Gabriel
Milas Dragana
Schindelholz Benno
Schmid Gerard
Brigo Alessandro
Garcia Gabriel
Milas Dragana
Schindelholz Benno
Schmid Gerard
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