Hydrazono-malonitriles

Details Hydrazono-malonitriles Hydrazono-malonitriles

C - Chemistry, Metallurgy

07

D

C07D 237/04 (2006.01) A61K 31/50 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2465746

Hydrazono-malonitrile derivatives of the formula (I) in which R1, R2, R3, R3' and R4 have the meanings given in Claim 1 act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumours, cachexia, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases, myocardial diseases and AIDS.

L'invention concerne des dérivés hydrazono-malonitriles de formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?3'¿ et R?4¿ sont tels que définis dans la revendication 1. Ces dérivés agissent en tant qu'inhibiteurs de la phosphodiestérase IV, et ils peuvent être utilisés dans le traitement de l'ostéoporose, des tumeurs, de la cachexie, de l'athérosclérose, de la polyarthrite rhumatoïde, de la sclérose en plaques, du diabète sucré, des processus inflammatoires, des allergies, de l'asthme, des maladies auto-immunes, des maladies myocardiques et du SIDA.

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