Hydrochloride salt of...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/52 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2761256

Disclosed is a compound of formula (I); crystalline forms thereof, and solvates thereof; pharmaceutical compositions comprising a pharmaceutically effective amount of the compound of formula (I), or a crystalline form thereof, or a solvate thereof, and a pharmaceutically acceptable carrier or diluent; and the use of a compound of formula (I), or a crystalline form thereof, or a solvate thereof, for treating a patient suffering from, or subject to, a pathological condition capable of being ameliorated by inhibiting an El activating enzyme, particularly NAE, including, e.g., cancer.

La présente invention a pour objet un composé de formule (I) ; ses formes cristallines, et ses solvates ; des compositions pharmaceutiques comprenant une quantité pharmaceutiquement efficace du composé de formule (I), ou d'une forme cristalline de celui-ci, ou d'un solvate de celui-ci, et un support ou un diluant pharmaceutiquement acceptable ; et l'utilisation d'un composé de formule (I), ou d'une forme cristalline de celui-ci, ou d'un solvate de celui-ci, pour le traitement d'un patient souffrant d'un état pathologique, ou sujet à un état pathologique capable d'être amélioré par l'inhibition d'une enzyme d'activation E1, en particulier la NAE, comprenant, par exemple, le cancer.

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