Hydrocortisone - 17, 21-diesters and method of the...

Details Hydrocortisone - 17, 21-diesters and method of the... Hydrocortisone - 17, 21-diesters and method of the...

C - Chemistry, Metallurgy

07

J

260/76

C07J 5/00 (2006.01)

Patent

CA 1135253

ABSTRACT OF THE DISCLOSURE The specification relates to hydrocortisone-17-21- diesters of general Formula Image (I) wherein R1 and R2 are the same or different and designate each a straight-chain or branched alkyl residue with 1-5 carbon atoms. The specification also discloses the production of same and the use of same in pharmaceutical preparation. Furthermore, the specification relates to hydrocortisone-17-propionate, method of its production and also to its use as an intermediate product for the production of hydrocortisone-17-propionate-21-esters according to Formula 1. The above new 17,21-diesters possess considerable advantages over 21-monoesters and 17-monoesters of hydrocortisone, as well as over halogenized corticosteroids. They possess good chemical stability and thus are particularly suitable for use in preparations for topical application when produced in a dissolved form. They possess valuable therapeutic proper.ties such as a good antiphlogistic effect combined with a low toxicity and thus do not produce certain undesired side effects typical in many corticosteroids.

329780

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